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Identification Summary. Eperisone is an antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles.. Generic Name Eperisone DrugBank Accession Number DB08992 Background. Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and.
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Patent application title: NOVEL FORMS OF EPERISONE Inventors: Isabel Kalofonos (Cambridge, MA, US). Patent application number: 20120196895. Abstract: The invention relates to novel crystalline forms of (2RS)-1-(4-ethylphenyl)-2-methyl-3-piperidin-1-yl-propan-1-one. The preparation and characterization of the novel crystalline forms according.
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Eperisone is an antispasmodic drug approved in Japan for the treatment of of diseases characterized by muscle stiffness and pain. It is believed that eperisone exerts its effect through inhibition of sodium channels. The drug is still being marketed in Asia under the name Myonal (Square Pharmaceuticals).
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Eperisone is a medicine that works by relaxing both vascular smooth muscles and skeletal muscles, and demonstrates a variety of effects such as improvement of circulation, reduction of myotonia and suppression of the pain reflex. It improves tinnitus and dizziness associated with certain other disorders. It is also used as a supporting drug during initial stages of subsequent rehabilitative.
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Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropriophenone hydrochloride) (Figure 1) is widely used for treatment of diseases with associated muscle stiffness and pain. In a trial in-volving 200 patients with myelopathy or spastic paraparesis, motor disability was significantly im-proved in 69.5% of patients by oral prednisolone.
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Deskripsi. EPERISONE TABLET merupakan obat yang mengandung Eperisone HCl. Eperisone HCl bekerja sebagai relaksan otot atau melemaskan otot rangka dan otot polos vaskular, yang menghasilkan pengurangan myotonia, peningkatan sirkulasi, dan penekanan refleks rasa sakit. EPERISONE digunakan untuk pengobatan simtomatik terhadap kondisi yang terkait.
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Eperisone adalah obat untuk mengatasi ketegangan otot atau melemaskan otot yang kaku sehingga dapat meredakan nyeri otot. Eperisone tidak boleh digunakan sembarangan dan harus dikonsumsi sesuai resep dokter.. Tegang pada otot bisa disebabkan oleh aktivitas fisik yang berlebihan, kurangnya peregangan, dehidrasi, ketidakseimbangan elektrolit, atau gangguan sirkulasi darah.
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It is a member of piperidines and an aromatic ketone. ChEBI. Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.
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Eperisone hydrochloride of the following formula (II) can be prepared for example, by the process of Example 1 of GB 1452868 or the equivalent Japanese Patent Publication No. 27914/1980. [0011] The physico-chemical properties of this compound are as follows: molecular formula: C₁₇H₂₅NO.HC1. molecular weight: 295.85.
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Introduction. Low back pain (LBP) is a common complaint and occurs in more than 80% of the population.1 It refers to an unpleasant sensory and emotional experience associated with actual or potential tissue damage felt near the mid-line in the lumbar or sacral region.2 The prevalence of low back pain is approximately 38.4%, more than one third among the productive age population.
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Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP). The present systematic review evaluates the efficacy and safety of eperisone in patients with LBP. Cochrane Back and Neck (CBN) Group and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.
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Disclosed is a method for preparing eperisone hydrochloride by an one-pot reaction and a filtration process. The method for preparing eperisone hydrochloride comprises: a step of synthesizing eperisone hydrochloride by making 4′-ethyl propiophenone react with paraformaldehyde and piperidine hydrochloride in an organic solvent, and making non-reacted paraformaldehyde react with piperidine.
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2009-08-03 Priority to US13/057,542 priority Critical patent/US20110281911A1/en 2011-11-17 Publication of US20110281911A1 publication Critical patent/US20110281911A1/en. Racemic eperisone hydrochloride has a positive indication for the improvement of myotonic conditions caused by neck-shoulder-arm syndrome, scapulohumeral periarthritis, and.
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This study tests the hypothesis that radial extracorporeal shock wave therapy (rESWT) in combination with the non-steroidal anti-inflammatory drug Celecoxib and the antispasmodic drug Eperisone (hereafter, "C-E drug therapy") is statistically significantly more effective than either rESWT or C-E drug therapy alone in the treatment of chronic non-specific low back pain.